The I-Bresis hybrid iontophoresis system has the power to deliver optimal drug delivery and flexible, time-saving treatment options. The three treatment modes and the ability to deliver medication with positive or negative polarity, allows clinicians to choose the right medication and right application for each patient. The I-Bresis Mode powers a 3-minute Skin Conductivity Enhancement to help break down the skin's resistance, resulting in a 40-80mA-min treatment in approximately 1-2 hours. The I-Bresis Patch provides a fill-and-go efficiency. Built-in batteries plus dose controller activation allows quick and effective application. The direct current drives penetration by opening pathways to the skin. Compared to passive delivery, the I-Bresis Patches delivers a greater benefit from each treatment, ensuring more medication reaches the target tissue.